Danae Schulz
Associate Professor of Biology
F.W. Olin Science Center, Room 2351
1250 N. Dartmouth Ave.
Claremont, CA 91711
909.621.8767
dschulz@hmc.edu
Education and Professional Experience
- B.A., Biology, Tufts University
- B.M., Violin performance, New England Conservatory
- Ph.D., Molecular and Cell Biology, University of California Berkeley
- Postdoctoral Research Fellow, Rockefeller University
- Visiting Assistant Professor, Bard College
Teaching
- Bio 111: Molecular Biology Lab (Fall)
- Bio 189: Topics in Biochemistry and Molecular Biology (Fall)
- Bio 160: Molecular Immunology (Spring)
- Bio 52: Introduction to Biology (Spring)
- Bio 23: Biology Laboratory (Spring)
Research Interests
Danae studies the African trypanosome, a protozoan parasite that causes sleeping sickness in humans and nagana in cattle. Trypanosomes are transmitted to the bloodstream of a mammal through the bite of a tsetse fly, eventually leading to coma and death. Danae would like to understand what allows trypanosomes to reprogram themselves to adapt as they move between the differing environments of the fly midgut and the mammalian bloodstream, with an eye toward trying to manipulate these adaptations to generate new therapies. See also, Lab web page.
Website
Selected Publications
Parasite Papers
*indicates undergraduate co-author, ¨indicates corresponding author
*Miller G, *Rollosson LM, *Saada C, *Wade SJ, ¨Schulz D. 2023. Adaptation of CUT&RUN for use in African trypanosomes. PLoS One. 2023 Nov 21;18(11):e0292784. doi: 10.1371/journal.pone.0292784.
Poli ANR , *Blyn RC , *Buenconsejo, GY , Hodanu M , Tang E , Danh C , Cassel J ,Debler EW, ¨Schulz D ,Salvino, JM. 2023. Synthesis and characterization of I-BET151 derivatives for use in identifying protein targets in the African trypanosome. Current Research in Chemical Biology. Volume 3, 2023, 100047. doi: 10.1016/j.crchbi.2023.100047
Azizan S, Selvarajah SA, Tang J, Jeninga MD, Schulz D, Pareek K, Herr T, Day KP, De Koning-Ward TF, Petter M, Duffy MF. 2023. The P. falciparum alternative histones Pf H2A.Z and Pf H2B.Z are dynamically acetylated and antagonized by PfSir2 histone deacetylases at heterochromatin boundaries. mBio. 2023 Oct 26:e0201423. doi: 10.1128/mbio.02014-23
*Ashby, EC, *Havens, JL, *Rollosson, LM, Hardin, J, ¨Schulz, D. 2023 Apr 25:e0014723. Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the Transcriptome. Microbiology Spectrum. doi: 10.1128/spectrum.00147-23
*Ashby EC, *Paddock L, *Betts HL, *Liao J, *Miller G, *Porter A, *Rollosson LM, *Saada C, Tang E, *Wade SJ, Hardin J, ¨Schulz D. 2022. Genomic occupancy of the bromodomain protein Bdf3 is Dynamic during differentiation of African trypanosomes from bloodstream to procylic forms. mSphere. 2022 Jun 1:e0002322. doi: 10.1128/msphere.00023-22.
*Walsh, ME, *Naudzius, EM, *Diaz, SJ, *Wismar, TW, Martchenko Shilman, M, ¨Schulz, D. 2020. Identification of clinically approved small molecules that inhibit growth and affect transcript levels of developmentally regulated genes in the African trypanosome. PLoS Negl Trop Disease. 2020 Mar 13;14(3):e0007790. doi: 10.1371/journal.pntd.0007790.
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Schulz, D. Mugnier, MR, Boothroyd, CE, Papavasiliou, FN. 2016. Detection of Variant Surface Glycoprotein switching by magnetic activated cell sorting and flow cytometry. Journal of Visual Experiments, Oct 19;(116). doi: 10.3791/54715
Schulz, D. Papavasiliou, F.N. 2016. The VEXing problem of monoallelic expression in the African trypanosome. Proc Natl Acad Sci U S A. Jun 17. pii: 201608546.
Mugnier, MR, Papavasiliou, FN, Schulz, D. 2016. Vesicles as Vehicles for Virulence. Trends Parasitol. 2016 Jun;32(6):435-6. doi: 10.1016.
Schulz, D, Papavasiliou, FN, Kim, HS. 2016. Base J and H3.V regulate transcriptional termination in Trypanosoma brucei. PLoS Genet 12(1): e1005762
Schulz D, Mugnier MR, Paulsen E-M, Kim H-S, Chung C-wW, Tough DF et al. 2015. Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome. PLoS Biol 13(12): e1002316. [article]
Hovel-Miner G, Mugnier M, Papavasiliou FN, Pinger J, Schulz D. 2015. Springer, Results Probl Cell Differ. 57:23-46. A host-pathogen interaction reduced to first principles: antigenic variation in Trypanosoma brucei. Springer, Results Probl Cell Differ. 57:23-46.
Immunology Papers
Schulz, D, Vassen, L, Chow, K, Amin, RA, Moroy, T, Schlissel, MS. Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1. 2012. Journal of Experimental Medicine, Jan 16;209(1):187-99.
Chow, KT, Schulz, D, McWhirter, SM, Schlissel, MS. Gfi1 and Gfi1b repress Rag transcription in plasmacytoid dendritic cells in vitro. 2013. PLOS One. Sep24;8(9)e75891.
Schlissel, MS, Schulz, D, Vettermann, CA. Histone Code for Regulating V(D)J recombination. 2009. Molecular Cell, Jun 26;34(6):639-40.
Curry, JD, Schulz, D, Guidos, CJ, Danska JS, Nutter, L, Nussenzweig A, Schlissel MS. Chromosomal reinsertion of broken RSS ends during T cell development. 2007. J Ex Med, 204(10):2293-303
Degner SC, Verma-Gaur J, Wong TP, Bossen C, Iverson GM, Torkamani A, Vettermann C, Lin YC, Ju Z, Schulz D, et al. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. 2011.Proceedings of the National Academy of Sciences, Jun 7;108(23):9566-71
DNA Repair Papers
Gellon L, Razidlo DF, Gleeson O, Verra L, Schulz D, Lahue RS, Freudenreich CH. New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion. PLoS Genet. 2011 Feb 10;7(2):e1001298.
Articles about the Schulz lab
Radio broadcast for NPR’s Academic Minute
Danae Schulz receives NSF early career grant
Schulz joins multidisciplinary effort to detect and counteract emerging pathogens
Harvey Mudd biologists adapt DNA localization technique for parasite study