The project goal was to evaluate the switch from glass to plastic pre-filled syringes. This included experimental testing on the oxygen barrier properties of plastic, secondary packaging and oxygen absorbers, and experimental determination of the reaction mechanism of glutathione. These results were used to develop and refine an oxygen permeation model of a syringe and secondary pouch system. Patent research to investigate potential infringement and licensing was completed. Business and financial models were developed. * (KGI) Keck Graduate Institute