Modeling and Optimizing Bead-Based Immunoassays

Beckman-Coulter Inc. Mathematics, 2006-07

Liaison(s): Stephen L. Pentoney Jr., David L. Yang, Paul Kraght
Advisor(s): Henry Krieger
Students(s): Maureen St. Georges Chaumet (PM), Jason B. Santiago (PM), Krystle McBride, Daniel Percival, Aaron Tamura-Sato

The Prostate Specific Anitgen (PSA) Immunoassay is a diagnostic test developed by Beckman-Coulter Inc. which is used to assess prostate cancer risk. The Beckman-Coulter Mathematics Clinic team has been tasked with developing a mathematical model of such a system in order to improve the sensitivity and runtime of the test. The Clinic team developed a compartment-based model to assess the effects of vari-ous system parameters.