Modeling Bead-Based Immunoassays

Beckman Coulter, Inc. Mathematics, 2007-08

Liaison(s): Stephen L. Pentoney Jr., David L. Yang, Paul Kraght ’81, Veronica Colinayo
Advisor(s): Henry Krieger
Students(s): Nadia Abuelezam, Tracy Backes (PM), Catherine Bradshaw (S), David Gross, Brian Stock (F), Marielle Wardell

Beckman Coulter, Inc. produces a wide range of immunoassays as medical diagnostic tests. Using the prostate specific antigen (PSA) immunoassay, a test for diagnosing prostate cancer risk, last year’s Clinic team modeled the molecular interactions of bead-based immunoassays. This year’s team extended the previous model to encompass the entire immunoassay process, tested the effects of changing experimental parameters by performing the PSA immunoassay under varying conditions, and developed statistical tools to compare model simulations with experimental data.