Design of an Endoscopic Mucosal Metabolic Imaging Sensor using Diffuse Optical Spectroscopy and Optical Coherence Tomography

Beckman Laser Institute Engineering, 2009-10

Liaison(s): Albert Cerussi PhD, Zhonping Chen PhD, Sucbei Moon PhD, Bruce Tromberg PhD, Vasan Venugopalan PhD
Advisor(s): Qimin Yang
Students(s): Carolina de Freitas (TL-S), Susanna Lin (F), Benjamin Margolis, Roque Muna (S), Lauren Nishioku (S), Kevin Ryan (F), Matthew Streshinsky (F)

In trauma situations, the declination of fluids and metabolism in the patients’ body core quickly becomes irreversible after it begins. BLI has developed technologies that could quantitatively characterize mucosal tissue structure, blood flow, and oxygen utilization. The HMC Clinic team is asked to design, develop and demonstrate a mucosal metabolic imaging sensor, which combines two biophotonic technologies: Optical Coherence Tomography (OCT) and Diffuse Optical Spectrosopy (DOS). Using these technologies in conjunction will provide a robust and real-time measure of patient metabolism.