The Los Alamos National Laboratory (LANL) Clinic Team designed a strategy to reduce operating cost and environmental impact of the LANL supercomputing data center by minimizing water and energy consumption. The team created a thermodynamic model of the cooling system, identified and optimized the key parameters, and evaluated this strategy against a fixed-setpoint temperature approach. The strategy capitalizes on the wide range of Los Alamos, NM weather conditions by operating the system at settings optimized for ambient temperatures.