The 2019–2020 City of Hope Clinic team developed a comprehensive, remote rehabilitation and lymphedema care system which encompasses remote solutions using a mobile application and a simple and inexpensive at-home monitoring device. This includes addressing each of the practices used in current gold-standard care, particularly monitoring for changes in extracellular fluid using bioimpedance spectroscopy and educating and empowering patients on lymphedema prevention and management by expanding an existing mobile application.