The City of Hope Clinic team designed, built, and tested a device for use in minimally invasive brain tumor removal surgery. The device is inserted into the brain and used to fragment, cauterize, aspirate, and irrigate the site of a brain tumor, leaving a cavity for the delivery of anti-cancer macromolecules or cytotoxic cells. With this device, brain surgery will be made more efficient and effective, reducing both operation and patient recovery time.