Many of the most critical medications are injected directly into veins, arteries, or muscles using an IV system. The flow through traditional IV systems is driven by direct displacement mechanisms such as pistons or peristaltic actuators with flow disruption detected by measuring pressure. Cardinal Health’s next generation of systems will combine active and passive components with a sensor (a current HMC Engineering Clinic project) that determines the instantaneous flow rate. The mathematics team designed a control algorithm that incorporates feedback from this sensor to more accurately regulate flow.